| First Author | Hernández-Sánchez M | Year | 2015 |
| Journal | Oncotarget | Volume | 6 |
| Issue | 19 | Pages | 17479-90 |
| PubMed ID | 26036260 | Mgi Jnum | J:251215 |
| Mgi Id | MGI:6103147 | Doi | 10.18632/oncotarget.4127 |
| Citation | Hernandez-Sanchez M, et al. (2015) RhoE is required for contact inhibition and negatively regulates tumor initiation and progression. Oncotarget 6(19):17479-90 |
| abstractText | RhoE is a small GTPase involved in the regulation of actin cytoskeleton dynamics, cell cycle and apoptosis. The role of RhoE in cancer is currently controversial, with reports of both oncogenic and tumor-suppressive functions for RhoE. Using RhoE-deficient mice, we show here that the absence of RhoE blunts contact-inhibition of growth by inhibiting p27Kip1 nuclear translocation and cooperates in oncogenic transformation of mouse primary fibroblasts. Heterozygous RhoE+/gt mice are more susceptible to chemically induced skin tumors and RhoE knock-down results in increased metastatic potential of cancer cells. These results indicate that RhoE plays a role in suppressing tumor initiation and progression. |
