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Publication : Mice lacking CD21 and CD35 proteins mount effective immune responses against Borrelia burgdorferi infection.

First Author  Jacobson AC Year  2007
Journal  Infect Immun Volume  75
Issue  4 Pages  2075-8
PubMed ID  17283093 Mgi Jnum  J:119763
Mgi Id  MGI:3703229 Doi  10.1128/IAI.01920-06
Citation  Jacobson AC, et al. (2007) Mice lacking CD21 and CD35 proteins mount effective immune responses against Borrelia burgdorferi infection. Infect Immun 75(4):2075-8
abstractText  CD21/35(-/-) mice, deficient in CD21 and CD35 (complement receptors 2 and 1, respectively), were infected with Borrelia burgdorferi to assess the role of these receptors in a chronic bacterial infection. Although CD21/35(-/-) mice on both C57BL/6 and BALB/c backgrounds produced less B. burgdorferi-specific antibodies than did wild-type mice, spirochete levels and arthritis severity were similar.
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