| Primary Identifier | MGI:3573778 | Allele Type | Targeted |
| Attribute String | Conditional ready, Null/knockout | Gene | Trp53 |
| Transmission | Germline | Strain of Origin | 129S4/SvJae |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A knock in strategy was used to introduce a loxP-Stop-loxP transcriptional stop element upstream of exon 2 and p.L25Q and p.W26S substitutions into exon 2 (TTATGG>CAATCG). Northern and Western blots of mutant MEFs treated with adeno-virus cre demonstrated that transcript and protein were expressed, respectively. No expression is seen without Cre expression. |
