Primary Identifier | MGI:3531486 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(LPV-TAg121)5Tvd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The transgene consists of a lymphotrophic papovavirus (LPV) enhancer/early promoter and a mutant SV40 T antigen sequence truncated after amino acid 121 followed by 11 missense residues. The resulting protein includes the RB1-binding region but lacks the small t antigen and Trp53 binding region. Regulatory sequences direct expression of the transgene in B- and T-lymphocytes and choroid plexus epithelium. |