| First Author | Cheng CF | Year | 2019 |
| Journal | Commun Biol | Volume | 2 |
| Pages | 389 | PubMed ID | 31667363 |
| Mgi Jnum | J:288820 | Mgi Id | MGI:6433424 |
| Doi | 10.1038/s42003-019-0624-y | Citation | Cheng CF, et al. (2019) Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3. Commun Biol 2:389 |
| abstractText | Billions of people have obesity-related metabolic syndromes such as diabetes and hyperlipidemia. Promoting the browning of white adipose tissue has been suggested as a potential strategy, but a drug still needs to be identified. Here, genetic deletion of activating transcription factor 3 (ATF3 (-/-) ) in mice under a high-fat diet (HFD) resulted in obesity and insulin resistance, which was abrogated by virus-mediated ATF3 restoration. ST32da, a synthetic ATF3 inducer isolated from Salvia miltiorrhiza, promoted ATF3 expression to downregulate adipokine genes and induce adipocyte browning by suppressing the carbohydrate-responsive element-binding protein-stearoyl-CoA desaturase-1 axis. Furthermore, ST32da increased white adipose tissue browning and reduced lipogenesis in HFD-induced obese mice. The anti-obesity efficacy of oral ST32da administration was similar to that of the clinical drug orlistat. Our study identified the ATF3 inducer ST32da as a promising therapeutic drug for treating diet-induced obesity and related metabolic disorders. |
