| Primary Identifier | MGI:3574899 | Allele Type | Spontaneous |
| Attribute String | Not Specified | Gene | Apoe |
| Inheritance Mode | Recessive | Strain of Origin | KOR |
| Is Recombinase | false | Is Wild Type | false |
| description | Northern blot analysis of liver RNA and immunoblot analysis of plasma from homozygous mice demonstrated lack of expression of Apoe RNA and protein. The phenotype is generally similar to that of targeted Apoe mutations on the same diet. Mice of the original mutant strain (SHL) exhibit more severe xanthoma and hypercholesterolemia, and at an earlier age, than do homozygous mice congenic for the mutation on three standard laboratory inbred-strain backgrounds. In contrast, atherosclerotic lesions of the aortae of congenic mutants are more extensive than those of SHL mice. SHL mice seldom survive past 12 months of age. |
| molecularNote | This mutation was shown to be an allele of Apoe by complementation testing against Apoetm1Unc and by observation of altered restriction fragment sizes upon Southern blot analysis using a partial Apoe cDNA probe. |
