| First Author | Chiamulera C | Year | 2001 |
| Journal | Nat Neurosci | Volume | 4 |
| Issue | 9 | Pages | 873-4 |
| PubMed ID | 11528416 | Mgi Jnum | J:97288 |
| Mgi Id | MGI:3575084 | Doi | 10.1038/nn0901-873 |
| Citation | Chiamulera C, et al. (2001) Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat Neurosci 4(9):873-4 |
| abstractText | Both ionotropic and metabotropic glutamate receptors (mGluRs) are involved in the behavioral effects of pyschostimulants; however, the specific contributions of individual mGluR subtypes remain unknown. Here we show that mice lacking the mGluR5 gene do not self-administer cocaine, and show no increased locomotor activity following cocaine treatment, despite showing cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA) levels similar to wild-type (WT) mice. These results demonstrate a significant contribution of mGlu5 receptors to the behavioral effects of cocaine, and suggest that they may be involved in cocaine addiction. |
