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Allele : Cald1<tm1Claw> caldesmon 1; targeted mutation 1, C-L Albert Wang

Primary Identifier  MGI:3576365 Allele Type  Targeted
Attribute String  Null/knockout Gene  Cald1
Transmission  Germline Strain of Origin  129X1/SvJ
Is Recombinase  false Is Wild Type  false
molecularNote  A construct containing three tandem stop codons in exon 3b and a neomycin resistance gene was inserted to interrupt transcription of the smooth muscle isoform. Exons 4 and 5 were deleted upon recombination. Lung, bladder, intestine and uterus of mutants showed the lack of smooth muscle isoform in Western blot analyses. The non-muscle isoform was translated at normal levels.
  • mutations:
  • Intragenic deletion,
  • Insertion
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

5 Publication categories

Trail: Allele