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Allele : Tg(Cd4-TGFBR2)16Flv transgene insertion 16, Richard A Flavell
Primary Identifier  MGI:3575738 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(Cd4-TGFBR2)16Flv
Strain of Origin  C57BL/6 x C3H Is Recombinase  false
Is Wild Type  false
molecularNote  This transgene contains the mouse CD4 antigen promoter, sequence encoding the extracellular and transmembrane regions, nucleotides -7 and +573, of the human transforming growth factor, beta receptor II (70/80kDa) and a polyadenylation signal. Transgene expression is detected by RT-PCR analysis of thymus tissue, and is at a level sufficient to block TGF-beta signaling specifically in T cells.
  • mutations:
  • Insertion
  • synonyms:
  • CD4dn-TGF-RII,
  • dnTbetaRII,
  • CD4-dnTGFBRII,
  • CD4dnTgfbr2,
  • dnTGF-betaRII,
  • dnTGF-betaRII,
  • CD4dnTGFbetaRII,
  • dnTGFbetaRII,
  • dnTbetaRII,
  • dnTgfbr2<+>,
  • dnTgfbr2<+>,
  • dnTGFbetaRII,
  • CD4dnTGFbetaRII,
  • CD4dn-TGF-RII,
  • CD4dnTgfbr2,
  • CD4-dnTGFBRII
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

72 Publication categories





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