| First Author | Gropp E | Year | 2005 |
| Journal | Nat Neurosci | Volume | 8 |
| Issue | 10 | Pages | 1289-91 |
| PubMed ID | 16158063 | Mgi Jnum | J:101715 |
| Mgi Id | MGI:3604850 | Doi | 10.1038/nn1548 |
| Citation | Gropp E, et al. (2005) Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci 8(10):1289-91 |
| abstractText | Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis. |
