| First Author | Zheng QY | Year | 2004 |
| Journal | Acad J Xian Jiaotong Univ | Volume | 25 |
| Issue | 3 | Pages | 209-212 |
| PubMed ID | 21179397 | Mgi Jnum | J:175136 |
| Mgi Id | MGI:5142477 | Citation | Zheng QY, et al. (2004) Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10. Acad J Xian Jiaotong Univ 25(3):209-212 |
| abstractText | OBJECTIVE: to map a mouse deafness gene, identify the underlying mutation and develop a mouse model for human deafness. METHODS: genetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice. RESULTS: 1. hml was mapped on mouse Chr 10 (~43 cM from the centromere) suggests that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). 2. This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500kb area. |
