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Publication : Detailed mapping of the Rfv-1 gene that influences spontaneous recovery from Friend retrovirus-induced leukaemia.

First Author  Miyazawa M Year  1992
Journal  Eur J Immunogenet Volume  19
Issue  3 Pages  159-64
PubMed ID  1627536 Mgi Jnum  J:1094
Mgi Id  MGI:49626 Doi  10.1111/j.1744-313x.1992.tb00054.x
Citation  Miyazawa M, et al. (1992) Detailed mapping of the Rfv-1 gene that influences spontaneous recovery from Friend retrovirus-induced leukaemia. Eur J Immunogenet 19(3):159-64
abstractText  Using H-2 recombinant and mutant mice, the Rfv-1 gene influencing spontaneous recovery from Friend retrovirus (FV)-induced leukaemia was mapped in the D locus. Two Db alleles were required for full recovery, and a single Dd transgene did not convey increased susceptibility to FV in the presence of homozygous Db/b genotype. The results suggest that an increase in the expression of Db may lead to more effective stimulation of FV-specific CTL.
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