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Allele : Plcg2<Ali5> phospholipase C, gamma 2; Abnormal limb 5

Primary Identifier	MGI:3577720	Allele Type	Chemically induced (ENU)
Gene	Plcg2	Inheritance Mode	Dominant
Strain of Origin	C3HeB/FeJ	Is Recombinase	false
Is Wild Type	false

molecularNote

Sequencing revealed an A to G transition in exon 27, which would result in a aspartic acid to glycine substitution at position 993.

mutations:
Single point mutation

earliestPublication:
Yu P, et al. (2005) Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity 22(4):451-65

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

8 Publication categories

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