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Allele : Ppif<tm1Jmol> peptidylprolyl isomerase F (cyclophilin F); targeted mutation 1, Jeffery D Molkentin

Primary Identifier	MGI:3577093	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Ppif
Transmission	Germline	Strain of Origin	129
Is Recombinase	false	Is Wild Type	false

molecularNote

A neomycin resistance gene replaced the first three coding exons. Western blot of cardiac protein extracts from mutants demonstrated the lack of protein.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
Ppif<->,
Ppif<->

earliestPublication:
Baines CP, et al. (2005) Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434(7033):658-62

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

74 Publication categories

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