| First Author | Okada A | Year | 2012 |
| Journal | Neurosci Lett | Volume | 516 |
| Issue | 2 | Pages | 259-64 |
| PubMed ID | 22516460 | Mgi Jnum | J:188751 |
| Mgi Id | MGI:5441691 | Doi | 10.1016/j.neulet.2012.04.005 |
| Citation | Okada A, et al. (2012) Possible roles of Plexin-A4 in positioning of oligodendrocyte precursor cells in developing cerebral cortex. Neurosci Lett 516(2):259-64 |
| abstractText | Molecular mechanisms regulating positions of oligodendrocyte precursor cells (OPCs) remain unclear in developing cerebral cortex. To explore the mechanisms, we investigated how Plexin-A4, receptor of Semaphorin in OPCs, is involved in the positioning. We found that Plexin-A4 knockout mice exhibited (1) an increased number of OPCs in both the upper- and middle-regions of the cortical plate, where both indirect- and direct-ligands of Plexin-A4, Sema3A and Sema6A, respectively, were continuously expressed, and (2) aberrant distributions of OPCs in both the intermediate zone and corpus callosum, where Plexin-A4 was richly expressed in wild-type mice. These results suggest that Plexin-A4 is involved in the precise positioning of OPCs in developing cerebral cortex. |
