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Publication : MHC haplotype influences primary Giardia muris infections in H-2 congenic strains of mice.

First Author  Venkatesan P Year  1993
Journal  Int J Parasitol Volume  23
Issue  5 Pages  661-4
PubMed ID  8225770 Mgi Jnum  J:21687
Mgi Id  MGI:66400 Doi  10.1016/0020-7519(93)90174-w
Citation  Venkatesan P, et al. (1993) MHC haplotype influences primary Giardia muris infections in H-2 congenic strains of mice. Int J Parasitol 23(5):661-4
abstractText  The course of primary Giarda muris infections was studied in H-2 congenic strains of mice on the BALB and C57BL/10 (B10) genetic backgrounds. Infection was curtailed more rapidly in B10 strains, compared with BALB strains, and unaffected by H-2 haplotype. On the other hand the duration of infection in BALB strains did vary with H-2 haplotype with BALB/B(H-2b) mice taking significantly longer to clear infection than BALB/c(H-2d) and BALB/K(H-2k) mice. These experiments demonstrate that both MHC and non-MHC genes influence the outcome of primary G.muris infections.
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