| First Author | Sachs DH | Year | 1979 |
| Journal | J Immunol | Volume | 123 |
| Issue | 5 | Pages | 1965-9 |
| PubMed ID | 114582 | Mgi Jnum | J:109962 |
| Mgi Id | MGI:3630138 | Doi | 10.4049/jimmunol.123.5.1965 |
| Citation | Sachs DH, et al. (1979) Two new recombinant H-2 haplotypes, one of which juxtaposes Kb and Ik alleles. J Immunol 123(5):1965-9 |
| abstractText | Two new recombinant H-2 haplotypes have been detected and established as congenic resistant lines on the C57BL/10 background. On the basis of serologic testing and immunoprecipitation analyses, the sublocus composition of the first recombinant haplotype, H-2bq1 (B10.MBR) has been shown to be KbIkDq, and that of the second recombinant, H-2sq3 (B10.SQR) to be KsIsSsDq. The occurrence of the Kb I-Ak juxtaposition after a recombination between H-2b and H-2m contrasts with the almost uniform failure to observe H-2b/H-2k recombinants in previous studies. This finding and the occurrence of a second recombination event involving the same chromosome soon after the first in our studies may imply that recombination within H-2 is not generally a random event. The B10.MBR line has proved useful in the production of specific anti-H-2Kb and anti-I-Ab antisera previously quite difficult to obtain contamination by anti-Ia or anti-H-2K antibodies, respectively. |
