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Publication : Absence of neuroanatomical and behavioral deficits in L7/pcp-2-null mice.

First Author  Vassileva G Year  1997
Journal  Brain Res Mol Brain Res Volume  46
Issue  1-2 Pages  333-7
PubMed ID  9191112 Mgi Jnum  J:40442
Mgi Id  MGI:87786 Doi  10.1016/s0169-328x(97)00081-8
Citation  Vassileva G, et al. (1997) Absence of neuroanatomical and behavioral deficits in L7/pcp-2-null mice. Brain Res Mol Brain Res 46(1-2):333-7
abstractText  L7/pcp-2 is expressed exclusively in cerebellar Purkinje and retinal bipolar neurons. While the function of L7/pcp-2 is unknown, its mRNA is trafficked into dendrites, suggesting a role in dendritic physiology. To elucidate its function, L7/pcp-2-null mice were generated. These mice are neurologically normal with no signs of cerebellar or retinal dysfunction. The mice are indistinguishable from wild-type littermates with regards to gross neuroanatomy and fine structure of Purkinje cell dendrites.
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