| Primary Identifier | MGI:3579440 | Allele Type | Targeted |
| Gene | Gabrg2 | Transmission | Germline |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A targeting vector was constructed to flank exon 8 with loxP sites. A neomycin selection cassette was placed downstream of exon 8, within the floxed sequence. Gene expression was demonstrated to be highly variable, ranging from 10-95% of normal, with the average reduction being 65%. Immunohistochemical analysis demonstrated that protein levels were variably reduced. |
