| First Author | Hard GC | Year | 1985 |
| Journal | Cancer Res | Volume | 45 |
| Issue | 2 | Pages | 703-8 |
| PubMed ID | 3155646 | Mgi Jnum | J:24857 |
| Mgi Id | MGI:72597 | Citation | Hard GC (1985) Identification of a high-frequency model for renal carcinoma by the induction of renal tumors in the mouse with a single dose of streptozotocin. Cancer Res 45(2):703-8 |
| abstractText | In order to develop a high-frequency, single-dose model of renal epithelial tumor induction in the mouse, streptozotocin (250 mg/kg) was administered i.v. to 6-week-old males and females of the CBA/H/T6J strain. In groups of 26 males and 30 females representing the effective number of survivors eligible for tumor estimates, renal cell tumors were found in 73% of males and 97% of females, including incidences of lesions diagnosed as renal carcinoma in 31 and 60%, respectively. The difference in renal tumor frequency between the sexes was not considered a real effect owing to the significantly decreased survival of the males. The neoplastic lesions ranged from small papillary or cystopapillary adenomas with a benign appearance to large, solid carcinomas with a low potential for metastasis. In the females, 22% of the larger tumors metastasized to distant sites, mainly the lungs. Intermediate lesions incorporating both papillary and solid adenomatous profiles suggested a sequential development of carcinomas along this pathway from the smaller papillary foci. The data establish the administration of a single dose of streptozotocin in the female CBA/H/T6J as a suitable high incidence model for the study of renal epithelial carcinogenesis in the mouse. |
