| First Author | Hou L | Year | 2022 |
| Journal | Front Immunol | Volume | 13 |
| Pages | 1040818 | PubMed ID | 36439108 |
| Mgi Jnum | J:331952 | Mgi Id | MGI:7397508 |
| Doi | 10.3389/fimmu.2022.1040818 | Citation | Hou L, et al. (2022) CD11c regulates late-stage T cell development in the thymus. Front Immunol 13:1040818 |
| abstractText | CD11c, also named integrin alphaX, has been deemed solely as a dendritic cell marker for decades while the delineation of its biological function was limited. In the current study, we observed in mice that CD11c deficiency led to a defect in T cell development, demonstrated by the loss of CD4(+)CD8(+) double positive (DP) T cells, CD4(+)CD8(-), and CD4(-)CD8(+) single positive (SP) T cells in the thymus and less mature T cells in the periphery. By using bone marrow chimera, we confirmed that CD11c regulated T cell development in the thymus. We further showed that CD11c deficiency led to an accelerated apoptosis of CD3 positive thymocytes, but not CD4(-)CD8(-) double negative (DN) T cells. Overall, this study added one more layer of knowledge on the regulatory mechanism of late-stage T cell development that the presence of CD11c in the thymus is critical for maintaining T cell survival. |
