| First Author | Tran SC | Year | 2021 |
| Journal | Neuroscience | Volume | 455 |
| Pages | 30-38 | PubMed ID | 33346119 |
| Mgi Jnum | J:305360 | Mgi Id | MGI:6709963 |
| Doi | 10.1016/j.neuroscience.2020.12.003 | Citation | Tran SC, et al. (2021) Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected Behaviours in Adult Mice. Neuroscience 455:30-38 |
| abstractText | The proto-oncogene pleomorphic adenoma gene 1 (Plag1) encodes a zinc finger transcription factor. PLAG1 is part of the high motility group AT hook-2 (HGMA2)-PLAG1-insulin-like growth factor 2 (IGF2) pathway that, when disrupted, leads to Silver-Russell syndrome, a severe form of intrauterine growth restriction. With little known about PLAG1's role in normal physiology, this study is the first to characterise the behavioural phenotype of PLAG1-deficient mice. Mice were tested for differences in circadian locomotor activity and body temperature, sleep-like behaviour, anxiety-like behaviour, cognition, social behaviour, and sensorimotor gating. Overall, the behavioural phenotype of the Plag1 knock-out (KO) mice was mild: no significant differences were seen in circadian activity levels, locomotion, object recognition, spatial memory or sociability compared to wild-type mice. However, the cued test of fear conditioning, prepulse inhibition of the startle response and Preyer's reflex test suggest that Plag1 KO mice may have a hearing impairment. This implies that PLAG1 plays an important role in proper functioning and/or development of the neural circuitry behind the auditory processes or interacts with genes involved in those processes. |
