| First Author | Howie D | Year | 2005 |
| Journal | J Immunol | Volume | 174 |
| Issue | 10 | Pages | 5931-5 |
| PubMed ID | 15879084 | Mgi Jnum | J:98995 |
| Mgi Id | MGI:3580948 | Doi | 10.4049/jimmunol.174.10.5931 |
| Citation | Howie D, et al. (2005) Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions. J Immunol 174(10):5931-5 |
| abstractText | Ly108, a glycoprotein of the signaling lymphocytic activation molecule family of cell surface receptors expressed by T, B, NK, and APCs has been shown to have a role in NK cell cytotoxicity and T cell cytokine responses. In this study, we describe that CD4(+) T cells from mice with a targeted disruption of exons 2 and 3 of Ly108 (Ly108(DeltaE2+3)) produce significantly less IL-4 than wild-type CD4(+) cells, as judged by in vitro assays and by in vivo responses to cutaneous infection with Leishmania mexicana. Surprisingly, neutrophil functions are controlled by Ly108. Ly108(DeltaE2+3) mice are highly susceptible to infection with Salmonella typhimurium, bactericidal activity of Ly108(DeltaE2+3) neutrophils is defective, and their production of IL-6, IL-12, and TNF-alpha is increased. The aberrant bactericidal activity by Ly108(DeltaE2+3) neutrophils is a consequence of severely reduced production of reactive oxygen species following phagocytosis of bacteria. Thus, Ly108 serves as a regulator of both innate and adaptive immune responses. |
