| First Author | Lu YC | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 355 |
| Issue | 1 | Pages | 23-7 |
| PubMed ID | 17291451 | Mgi Jnum | J:118626 |
| Mgi Id | MGI:3699989 | Doi | 10.1016/j.bbrc.2007.01.059 |
| Citation | Lu YC, et al. (2007) Transgenic insulin released from G cells preferentially signals in the liver. Biochem Biophys Res Commun 355(1):23-7 |
| abstractText | We have previously produced transgenic G-InsKi mice, a model allowing regulated portal insulin delivery from gastric G cells without using beta cells. Here, we report that in G-InsKi mice portal levels of transgenic human insulin are 6-fold higher than in peripheral circulation. Peptone-induced release of transgenic human insulin from G cells preferentially stimulated signaling cascades in the liver rather than in peripheral insulin-sensitive tissues, as judged by tyrosine phosphorylation of insulin receptor beta subunit and phosphorylation of protein kinase Akt/PKB at Thr-308. G-InsKi mice provide a novel animal model for elucidating direct effects of insulin on liver functions. |
