Primary Identifier | MGI:3582638 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change, Reporter | Gene | Bdnf |
Transmission | Germline | Strain of Origin | 129S2/SvPas |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A targeting construct was designed to flank the pro encoding region and mature hormone-encoding region of exon V with loxP sites, with a trimerized polyadenylation signal upstream of the 3' loxP sequence and a lacZ gene and FRT-flanked neomycin resistance cassette downstream of the 3' loxP sequence. Cre mediated excision would enable transcription and translation of lacZ in place of Bdnf. |