Primary Identifier | MGI:3583655 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Sin3a |
Transmission | Germline | Strain of Origin | 129 |
Is Recombinase | false | Is Wild Type | false |
description | Homozygous MEFs infected with viral cre stop proliferating, display increased apoptosis, and show G2/M and S phase cell cycle arrest; however, no increase in chromosomal instability is seen. Similar results are seen when MEFs are infected with a tamoxifen inducible cre/estrogen receptor construct. (J:99406) |
molecularNote | LoxP sites were inserted to flank exon 4. |