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Allele : Sin3a<tm1Rdp> transcriptional regulator, SIN3A (yeast); targeted mutation 1, Ronald DePinho

Primary Identifier  MGI:3583655 Allele Type  Targeted
Attribute String  Conditional ready, No functional change Gene  Sin3a
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
description  Homozygous MEFs infected with viral cre stop proliferating, display increased apoptosis, and show G2/M and S phase cell cycle arrest; however, no increase in chromosomal instability is seen. Similar results are seen when MEFs are infected with a tamoxifen inducible cre/estrogen receptor construct. (J:99406)
molecularNote  LoxP sites were inserted to flank exon 4.
  • mutations:
  • Insertion
  • synonyms:
  • mSin3A<L>,
  • mSin3A<L>,
  • Sin3a<Flox>,
  • Sin3a<Flox>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

17 Publication categories