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Allele : **Tg(Col2a1-PTHR1*H223R)AHju** transgene insertion A, Harald Juppner

Primary Identifier	MGI:3584013	Allele Type	Transgenic
Attribute String	Constitutively active, Humanized sequence, Inserted expressed sequence	Gene	*Tg(Col2a1-PTHR1H223R)AHju**
Strain of Origin	C57BL/6	Is Recombinase	false
Is Wild Type	false

molecularNote

A 1,880-bp cDNA fragment encoding the constitutively active human PTHR1 containing an H223R mutation (HKrk-H223R) was placed downstream of the rat alpha (II) collagen promoter. The A line contains only one copy of the transgene.

mutations:
Insertion

synonyms:
Tg-A,
CaPpr,
Tg-A,
CaPpr

earliestPublication:
Schipani E, et al. (1997) Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc Natl Acad Sci U S A 94(25):13689-94

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

9 Publication categories

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Allele : Tg(Col2a1-PTHR1*H223R)AHju transgene insertion A, Harald Juppner

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