| First Author | Sun D | Year | 2019 |
| Journal | Cell Rep | Volume | 27 |
| Issue | 5 | Pages | 1461-1471.e4 |
| PubMed ID | 31042473 | Mgi Jnum | J:281870 |
| Mgi Id | MGI:6380964 | Doi | 10.1016/j.celrep.2019.04.014 |
| Citation | Sun D, et al. (2019) Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. Cell Rep 27(5):1461-1471.e4 |
| abstractText | B cell lymphoma-6 (BCL6) is highly expressed in germinal center B cells, but how its expression is maintained is still not completely clear. Aryl hydrocarbon receptor interacting protein (AIP) is a co-chaperone of heat shock protein 90. Deletion of Aip in B cells decreased BCL6 expression, reducing germinal center B cells and diminishing adaptive immune responses. AIP was required for optimal AKT signaling in response to B cell receptor stimulation, and AIP protected BCL6 from ubiquitin-mediated proteasomal degradation by the E3-ubiquitin ligase FBXO11 by binding to the deubiquitinase UCHL1, thus helping to maintain the expression of BCL6. AIP was highly expressed in primary diffuse large B cell lymphomas compared to healthy tissue and other tumors. Our findings describe AIP as a positive regulator of BCL6 expression with implications for the pathobiology of diffuse large B cell lymphoma. |
