| First Author | Taketomi T | Year | 2005 |
| Journal | Nat Neurosci | Volume | 8 |
| Issue | 7 | Pages | 855-7 |
| PubMed ID | 15937482 | Mgi Jnum | J:99827 |
| Mgi Id | MGI:3583882 | Doi | 10.1038/nn1485 |
| Citation | Taketomi T, et al. (2005) Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Nat Neurosci 8(7):855-7 |
| abstractText | We report here that loss of the Sprouty2 gene (also known as Spry2) in mice resulted in enteric nerve hyperplasia, which led to esophageal achalasia and intestinal pseudo-obstruction. Glial cell line-derived neurotrophic factor (GDNF) induced hyperactivation of ERK and Akt in enteric nerve cells. Anti-GDNF antibody administration corrected nerve hyperplasia in Sprouty2-deficient mice. We show Sprouty2 to be a negative regulator of GDNF for the neonatal development or survival of enteric nerve cells. |
