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Allele : Del(2Dlx1-Dlx2)1Jlr deletion, Chr 2, John L R Rubenstein 1

Primary Identifier	MGI:3586512	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Del(2Dlx1-Dlx2)1Jlr
Transmission	Germline	Strain of Origin	129X1/SvJ
Is Recombinase	false	Is Wild Type	false

molecularNote

A 15.6 kb deletion removes all of exons 2 and 3 of both Dlx1 and Dlx2 and the entire intergenic region and replaces it with a neomycin resistance gene.

mutations:
Insertion,
Intragenic deletion,
Intergenic deletion

cellLines:
Not Specified

synonyms:
D1x-1&2-D15.6/neo,
Dlx1/2-,
Dlx1/2-,
D1x-1&2-D15.6/neo,
Dlx1/Dlx2<tm2Jlr>,
Dlx1&2-null,
Dlx1/Dlx2<tm2Jlr>,
Dlx1&2-null

earliestPublication:
Qiu M, et al. (1997) Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches. Dev Biol 185(2):165-84

1 Feature

Genome

0 Expresses

7 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

40 Publication categories

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