| First Author | Yu G | Year | 2001 |
| Journal | Brain Res Dev Brain Res | Volume | 130 |
| Issue | 2 | Pages | 217-30 |
| PubMed ID | 11675124 | Mgi Jnum | J:73104 |
| Mgi Id | MGI:2154576 | Doi | 10.1016/s0165-3806(01)00239-5 |
| Citation | Yu G, et al. (2001) Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins. Brain Res Dev Brain Res 130(2):217-30 |
| abstractText | The DLX homeodomain proteins control development of the basal ganglia and branchial arches. To identify co-factors that regulate DLX function we utilized the yeast two-hybrid assay, and found a DLX interacting protein (DIP2) which binds to the N-terminal region of DLX2 via a PDZ domain. DIP2 appears to be an alternatively spliced form of GRIP1, a protein known to bind AMPA glutamate receptors via PDZ domains. Thus, we named it GRIP1b. We provide evidence that GRIP1b can function as a transcriptional co-activator of DLX2 and DLX5. Glutamate receptors inhibit this co-activation. These results suggest that some PDZ proteins may regulate transcription via their interactions with homeodomain proteins. Furthermore, these results suggest a link between glutamate receptors, PDZ proteins and the DLX transcription factors, all of which are co-expressed in the developing basal ganglia. |
