| First Author | Nosten-Bertrand M | Year | 1996 |
| Journal | Nature | Volume | 379 |
| Issue | 6568 | Pages | 826-9 |
| PubMed ID | 8587606 | Mgi Jnum | J:31610 |
| Mgi Id | MGI:79096 | Doi | 10.1038/379826a0 |
| Citation | Nosten-Bertrand M, et al. (1996) Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1. Nature 379(6568):826-9 |
| abstractText | The process of learning involves stable changes in synaptic efficacy for which long-term potentiation (LTP) provides a widely adopted mammalian model. Synaptic modification induced by learning or LTP may involve the action of cell adhesion molecules. One such candidate is the ubiquitous neuronal glycoprotein Thy-1. In mice in which the gene encoding Thy-1 has been inactivated, we find a regionally selective impairment of LTP in vivo in the hippocampal formation: LTP is normal in area CA1 but strongly inhibited in the dentate gyrus. Spatial learning by Thy-1-deficient mice, as assessed in the watermaze, is unimpaired. Thus LTP in the cortical input to the dentate gyrus seems not to be required for spatial learning. |
