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Allele : Gt(ROSA)26Sor<tm1(rtTA2S*M2)Whsu> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Wei Hsu
Primary Identifier  MGI:3584142 Allele Type  Targeted
Attribute String  Conditional ready, Transactivator Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
molecularNote  A synthetic modified version of the rtTA gene preceded by a loxP flanked STOP sequence was inserted into the Gt(ROSA)26Sor locus. This version of rtTA contains 5 amino acid changes in the TetR moiety (S12G, E19G, A56P, D148E, and H179R) and a synthetic optimized transactivating domain. This rtTA has reduced basal activity and enhanced doxycycline sensitivity compared to wild-type rtTA.
  • mutations:
  • Insertion
  • synonyms:
  • R26STOPrtTA,
  • R26STOPrtTA,
  • Gt(ROSA)26Sor<tm1(xstpx-rtTA2S*M2)Whsu>,
  • Gt(ROSA)26Sor<tm1(xstpx-rtTA2S*M2)Whsu>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

7 Publication categories





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