| First Author | Liu Z | Year | 2022 |
| Journal | Cell Res | Volume | 32 |
| Issue | 2 | Pages | 139-156 |
| PubMed ID | 34848869 | Mgi Jnum | J:358862 |
| Mgi Id | MGI:7783822 | Doi | 10.1038/s41422-021-00588-5 |
| Citation | Liu Z, et al. (2022) A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state. Cell Res 32(2):139-156 |
| abstractText | Dopamine (DA) level in the nucleus accumbens (NAc) is critical for reward and aversion encoding. DA released from the ventral mesencephalon (VM) DAergic neurons increases the excitability of VM-projecting D1-dopamine receptor-expressing medium spiny neurons (D1-MSNs) in the NAc to enhance DA release and augment rewards. However, how such a DA positive feedback loop is regulated to maintain DA homeostasis and reward-aversion balance remains elusive. Here we report that the ventral pallidum (VP) projection of NAc D1-MSNs (D1(NAc-VP)) is inhibited by rewarding stimuli and activated by aversive stimuli. In contrast to the VM projection of D1-MSN (D1(NAc-VM)), activation of D1(NAc-VP) projection induces aversion, but not reward. D1(NAc-VP) MSNs are distinct from the D1(NAc-VM) MSNs, which exhibit conventional functions of D1-MSNs. Activation of D1(NAc-VP) projection stimulates VM GABAergic transmission, inhibits VM DAergic neurons, and reduces DA release into the NAc. Thus, D1(NAc-VP) and D1(NAc-VM) MSNs cooperatively control NAc dopamine balance and reward-aversion states. |
