| First Author | Kaushik S | Year | 2012 |
| Journal | EMBO Rep | Volume | 13 |
| Issue | 3 | Pages | 258-65 |
| PubMed ID | 22249165 | Mgi Jnum | J:196544 |
| Mgi Id | MGI:5488706 | Doi | 10.1038/embor.2011.260 |
| Citation | Kaushik S, et al. (2012) Loss of autophagy in hypothalamic POMC neurons impairs lipolysis. EMBO Rep 13(3):258-65 |
| abstractText | Autophagy degrades cytoplasmic contents to achieve cellular homeostasis. We show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases alpha-melanocyte-stimulating hormone (MSH) levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis. Ageing reduces hypothalamic autophagy and alpha-MSH levels, and aged-mice phenocopy, the adiposity and lipolytic defect observed in POMC neuron autophagy-null mice. Intraperitoneal isoproterenol restores lipolysis in both models, demonstrating normal adipocyte catecholamine responsiveness. We propose that an unconventional, autophagosome-mediated form of secretion in POMC neurons controls energy balance by regulating alpha-MSH production. Modulating hypothalamic autophagy might have implications for preventing obesity and metabolic syndrome of ageing. |
