| Primary Identifier | MGI:3587791 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Lmna |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Introns 10 and 11 and the last 150 nucleotides of exon 11 were deleted, thereby abolishing production of lamin C and producing a mutated prelamin A that precludes wild-type Lmna synthesis. A loxP flanked neo was inserted downstream of exon 12. Western blot of mutant MEFs demonstrated the expression of large amounts of mutant prelamin A. |
