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Allele : Lmna<tm1Lgf> lamin A; targeted mutation 1, Loren G Fong
Primary Identifier  MGI:3587791 Allele Type  Targeted
Attribute String  Null/knockout Gene  Lmna
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Introns 10 and 11 and the last 150 nucleotides of exon 11 were deleted, thereby abolishing production of lamin C and producing a mutated prelamin A that precludes wild-type Lmna synthesis. A loxP flanked neo was inserted downstream of exon 12. Western blot of mutant MEFs demonstrated the expression of large amounts of mutant prelamin A.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • Lmna<HG>,
  • Lmna<HG>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Carried By

Trail: Allele

0 Driven By

11 Publication categories

Trail: Allele




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