| First Author | Debrand E | Year | 2009 |
| Journal | FEBS J | Volume | 276 |
| Issue | 6 | Pages | 1610-28 |
| PubMed ID | 19220457 | Mgi Jnum | J:148426 |
| Mgi Id | MGI:3844779 | Doi | 10.1111/j.1742-4658.2009.06893.x |
| Citation | Debrand E, et al. (2009) Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms. FEBS J 276(6):1610-28 |
| abstractText | Talins are large adaptor proteins that link the integrin family of adhesion molecules to F-actin. In vertebrates, there are two talin genes. Talin 1 is essential for integrin-mediated cell adhesion; the role of talin 2 is unclear. Here we report a detailed analysis of mammalian talin 2. This reveals the existence of a previously unrecognized promoter associated with a CpG island, and separated from the first coding exon by numerous alternatively spliced noncoding exons spanning > 200 kb. Analysis of a mouse gene trap line shows that this promoter accounts for most of the talin 2 expression in adult tissues. We also demonstrate that testis and kidney express truncated talin 2 isoforms that lack the N-terminal half of the protein, and provide evidence for the developmentally regulated expression of the short testis-specific talin 2 isoform in elongating spermatids. Finally, we identify four tissue-specific alternative splicing events within the coding region of talin 2. |
