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Allele : Myo1a<tm1Mtys> myosin IA; targeted mutation 1, Matthew J Tyska

Primary Identifier	MGI:3587749	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Myo1a
Transmission	Germline	Strain of Origin	129S1/SvImJ
Is Recombinase	false	Is Wild Type	false

molecularNote

A neo/ura3 cassette replaced the first three exons. Absence of protein in mutants was confirmed by immunoblot of small intestines. Immunostaining of mutant duodenal sections with an antibody directed against the TH1 domain showed the expected lack of signal in mutants.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

earliestPublication:
Tyska MJ, et al. (2005) Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell 16(5):2443-57

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

8 Publication categories

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