| First Author | Alexander JJ | Year | 2007 |
| Journal | Nat Med | Volume | 13 |
| Issue | 6 | Pages | 685-7 |
| PubMed ID | 17515894 | Mgi Jnum | J:121897 |
| Mgi Id | MGI:3712607 | Doi | 10.1038/nm1596 |
| Citation | Alexander JJ, et al. (2007) Restoration of cone vision in a mouse model of achromatopsia. Nat Med 13(6):685-7 |
| abstractText | Loss of cone function in the central retina is a pivotal event in the development of severe vision impairment for many prevalent blinding diseases. Complete achromatopsia is a genetic defect resulting in cone vision loss in 1 in 30,000 individuals. Using adeno-associated virus (AAV) gene therapy, we show that it is possible to target cones and rescue both the cone-mediated electroretinogram response and visual acuity in the Gnat2 ( cpfl3 ) mouse model of achromatopsia. |
