Primary Identifier | MGI:3590192 | Allele Type | Chemically induced (ENU) |
Attribute String | Not Specified | Gene | Ccdc62 |
Inheritance Mode | Recessive | Strain of Origin | C57BL/6J |
Is Recombinase | false | Is Wild Type | false |
molecularNote | ENU mutagenesis created a C>T point mutation in exon 6, changing arginine codon CGA to stop codon TGA (p.Arg284Stop or p.R284*) in the highly conserved second coiled-coil domain. Western blot analysis showed the expression of a truncated peptide from this allele and qRT-PCR showed a significant reduction of mRNA expression from the allele in testes. |