| First Author | Tao Y | Year | 2013 |
| Journal | Nat Neurosci | Volume | 16 |
| Issue | 3 | Pages | 290-9 |
| PubMed ID | 23354328 | Mgi Jnum | J:197472 |
| Mgi Id | MGI:5493170 | Doi | 10.1038/nn.3320 |
| Citation | Tao Y, et al. (2013) Erbin interacts with TARP gamma-2 for surface expression of AMPA receptors in cortical interneurons. Nat Neurosci 16(3):290-9 |
| abstractText | Inhibitory neurons control the firing of glutamatergic neurons and synchronize brain activity. However, little is known about mechanisms of excitatory synapse formation in inhibitory neurons. Here we demonstrate that Erbin is specifically expressed in cortical inhibitory neurons. It localizes at excitatory synapses and regulates AMPA receptor (AMPAR) surface expression. Erbin mutation reduced mEPSCs and AMPAR currents specifically in parvalbumin (PV)-positive interneurons but not in pyramidal neurons. We found that the AMPAR auxiliary protein TARP gamma-2 was specifically expressed in cortical interneurons. Erbin interacts with TARP gamma-2 and is crucial for its stability. Deletion of the gamma-2-interacting domain in Erbin attenuated surface AMPAR and excitatory transmission in PV-positive interneurons. Furthermore, we observed behavioral deficits in Erbin-null mice and in mice expressing an Erbin truncation mutant that is unable to interact with TARP gamma-2. These observations demonstrate a crucial function for Erbin in AMPAR surface expression in cortical PV-positive interneurons and may contribute to a better understanding of psychiatric disorders. |
