| First Author | Vujovic M | Year | 2015 |
| Journal | Mol Cell Endocrinol | Volume | 416 |
| Pages | 19-26 | PubMed ID | 26319697 |
| Mgi Jnum | J:229174 | Mgi Id | MGI:5751008 |
| Doi | 10.1016/j.mce.2015.08.017 | Citation | Vujovic M, et al. (2015) Thyroid hormone drives the expression of mouse carbonic anhydrase Car4 in kidney, lung and brain. Mol Cell Endocrinol 416:19-26 |
| abstractText | Thyroid hormone is a well-known regulator of brain, lung and kidney development and function. However, the molecular mechanisms by which the hormone exerts its function have remained largely enigmatic, and only a limited set of target genes have been identified in these tissues. Using a mouse model with a mutation in thyroid hormone receptor alpha1 (TRalpha1), we here demonstrate that the expression of carbonic anhydrase 4 in lung and brain of the adult animal depends on intact TRalpha1 signaling. In the kidney, carbonic anhydrase 4 mRNA and protein are not affected by the mutant TRalpha1, but are acutely repressed by thyroid hormone. However, neither lung function--as measured by respiration rate and oxygen saturation--nor urine pH levels were affected by altered carbonic anhydrase 4 levels, suggesting that other carbonic anhydrases are likely to compensate. Taken together, our findings identify a previously unknown marker of TRalpha1 action in brain and lung, and provide a novel negatively regulated target gene to assess renal thyroid hormone status. |
