| First Author | Palladino G | Year | 2017 |
| Journal | J Mol Neurosci | Volume | 61 |
| Issue | 3 | Pages | 359-367 |
| PubMed ID | 27866325 | Mgi Jnum | J:311258 |
| Mgi Id | MGI:6757456 | Doi | 10.1007/s12031-016-0865-x |
| Citation | Palladino G, et al. (2017) Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease. J Mol Neurosci 61(3):359-367 |
| abstractText | Recent evidence highlights the protective role of reelin against amyloid beta (Abeta)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid beta precursor protein (AbetaPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Abeta-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Abeta-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Abeta-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model. |
