Primary Identifier | MGI:3590083 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell |
Strain of Origin | NOD/ShiLtJ | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The human CD4 gene lacking one exon but including its promoter was fused downstream of a mouse CD4 enhancer element then mixed with a large DNA fragment containing both HLA-DQA*0102 and HLA-DQB*0602 and injected into NOD/LtJ one celled embryos. A single founder line is maintained. |