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Allele : Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell transgene insertion N8, John F Elliott

Primary Identifier  MGI:3590083 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Strain of Origin  NOD/ShiLtJ Is Recombinase  false
Is Wild Type  false
molecularNote  The human CD4 gene lacking one exon but including its promoter was fused downstream of a mouse CD4 enhancer element then mixed with a large DNA fragment containing both HLA-DQA*0102 and HLA-DQB*0602 and injected into NOD/LtJ one celled embryos. A single founder line is maintained.
  • mutations:
  • Insertion
  • synonyms:
  • Tg(CD4,HLA-DQA1*0102,HLADQB1*0602)1Ell,
  • DQ6 transgene,
  • Tg(CD4,HLA-DQA1*0102,HLADQB1*0602)1Ell,
  • DQ6 transgene,
  • HLA-DQ6 transgene,
  • HLA-DQ6 transgene
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1 Feature

Genome

3 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

3 Carried By

0 Driven By

5 Publication categories