| First Author | Postnikov YV | Year | 2014 |
| Journal | Mol Cancer Res | Volume | 12 |
| Issue | 1 | Pages | 82-90 |
| PubMed ID | 24296759 | Mgi Jnum | J:206974 |
| Mgi Id | MGI:5553423 | Doi | 10.1158/1541-7786.MCR-13-0392 |
| Citation | Postnikov YV, et al. (2014) Loss of the nucleosome-binding protein HMGN1 affects the rate of N-nitrosodiethylamine-induced hepatocarcinogenesis in mice. Mol Cancer Res 12(1):82-90 |
| abstractText | We report that HMGN1, a nucleosome-binding protein that affects chromatin structure and function, affects the growth of N-nitrosodiethylamine (DEN)-induced liver tumors. Following a single DEN injection at 2 weeks of age, Hmgn1(tm1/tm1) mice, lacking the nucleosome-binding domain of HMGN1, had earlier signs of liver tumorigenesis than their Hmgn1(+/+) littermates. Detailed gene expression profiling revealed significant differences between DEN-injected and control saline-injected mice, but only minor differences between the injected Hmgn1(tm1/tm1) mice and their Hmgn1(+/+) littermates. Pathway analysis revealed that the most significant process affected by loss of HMGN1 involves the lipid/sterol metabolic pathway. Our study indicates that in mice, loss of HMGN1 leads to transcription changes that accelerate the progression of DEN-induced hepatocarcinogenesis, without affecting the type of tumors or the final total tumor burden of these mice. Implications: Loss of HMGN1 leads to accelerated progression of DEN-induced hepatocarcinogenesis in mice. |
