| First Author | Munguba H | Year | 2023 |
| Journal | Neuron | Volume | 111 |
| Issue | 22 | Pages | 3590-3603.e5 |
| PubMed ID | 37625400 | Mgi Jnum | J:342846 |
| Mgi Id | MGI:7561448 | Doi | 10.1016/j.neuron.2023.07.018 |
| Citation | Munguba H, et al. (2023) Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migration. Neuron 111(22):3590-3603.e5 |
| abstractText | Although cardinal cortical interneuron identity is established upon cell-cycle exit, it remains unclear whether specific interneuron subtypes are pre-established, and if so, how their identity is maintained prior to circuit integration. We conditionally removed Sox6 (Sox6-cKO) in migrating somatostatin (Sst(+)) interneurons and assessed the effects on their mature identity. In adolescent mice, five of eight molecular Sst(+) subtypes were nearly absent in the Sox6-cKO cortex without a reduction in cell number. Sox6-cKO cells displayed electrophysiological maturity and expressed genes enriched within the broad class of Sst(+) interneurons. Furthermore, we could infer subtype identity prior to cortical integration (embryonic day 18.5), suggesting that the loss in subtype was due to disrupted subtype maintenance. Conversely, Sox6 removal at postnatal day 7 did not disrupt marker expression in the mature cortex. Therefore, Sox6 is necessary during migration for maintenance of Sst(+) subtype identity, indicating that subtype maintenance requires active transcriptional programs. |
