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Publication : Neocortical inhibitory imbalance predicts successful sensory detection.

First Author  Deister CA Year  2024
Journal  Cell Rep Volume  43
Issue  7 Pages  114233
PubMed ID  38905102 Mgi Jnum  J:358790
Mgi Id  MGI:7709040 Doi  10.1016/j.celrep.2024.114233
Citation  Deister CA, et al. (2024) Neocortical inhibitory imbalance predicts successful sensory detection. Cell Rep 43(7):114233
abstractText  Perceptual success depends on fast-spiking, parvalbumin-positive interneurons (FS/PVs). However, competing theories of optimal rate and correlation in pyramidal (PYR) firing make opposing predictions regarding the underlying FS/PV dynamics. We addressed this with population calcium imaging of FS/PVs and putative PYR neurons during threshold detection. In primary somatosensory and visual neocortex, a distinct PYR subset shows increased rate and spike-count correlations on detected trials ("hits"), while most show no rate change and decreased correlations. A larger fraction of FS/PVs predicts hits with either rate increases or decreases. Using computational modeling, we found that inhibitory imbalance, created by excitatory "feedback" and interactions between FS/PV pools, can account for the data. Rate-decreasing FS/PVs increase rate and correlation in a PYR subset, while rate-increasing FS/PVs reduce correlations and offset enhanced excitation in PYR neurons. These findings indicate that selection of informative PYR ensembles, through transient inhibitory imbalance, is a common motif of optimal neocortical processing.
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