| First Author | Zhao R | Year | 2024 |
| Journal | Sci Adv | Volume | 10 |
| Issue | 31 | Pages | eadk4331 |
| PubMed ID | 39093969 | Mgi Jnum | J:358788 |
| Mgi Id | MGI:7708535 | Doi | 10.1126/sciadv.adk4331 |
| Citation | Zhao R, et al. (2024) Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally. Sci Adv 10(31):eadk4331 |
| abstractText | Homeostatic plasticity maintains the stability of functional brain networks. The axon initial segment (AIS), where action potentials start, undergoes dynamic adjustment to exert powerful control over neuronal firing properties in response to network activity changes. However, it is poorly understood whether this plasticity involves direct synaptic input to the AIS. Here, we show that changes of GABAergic synaptic input from chandelier cells (ChCs) drive homeostatic tuning of the AIS of principal neurons (PNs) in the prelimbic (PL) region, while those from parvalbumin-positive basket cells do not. This tuning is evident in AIS morphology, voltage-gated sodium channel expression, and PN excitability. Moreover, the impact of this homeostatic plasticity can be reflected in animal behavior. Social behavior, inversely linked to PL PN activity, shows time-dependent alterations tightly coupled to changes in AIS plasticity and PN excitability. Thus, AIS-originated homeostatic plasticity in PNs may counteract deficits elicited by imbalanced ChC presynaptic input at cellular and behavioral levels. |
