| First Author | Blot A | Year | 2021 |
| Journal | Neuron | Volume | 109 |
| Issue | 12 | Pages | 1996-2008.e6 |
| PubMed ID | 33979633 | Mgi Jnum | J:313897 |
| Mgi Id | MGI:6720563 | Doi | 10.1016/j.neuron.2021.04.017 |
| Citation | Blot A, et al. (2021) Visual intracortical and transthalamic pathways carry distinct information to cortical areas. Neuron 109(12):1996-2008.e6 |
| abstractText | Sensory processing involves information flow between neocortical areas, assumed to rely on direct intracortical projections. However, cortical areas may also communicate indirectly via higher-order nuclei in the thalamus, such as the pulvinar or lateral posterior nucleus (LP) in the visual system of rodents. The fine-scale organization and function of these cortico-thalamo-cortical pathways remains unclear. We find that responses of mouse LP neurons projecting to higher visual areas likely derive from feedforward input from primary visual cortex (V1) combined with information from many cortical and subcortical areas, including superior colliculus. Signals from LP projections to different higher visual areas are tuned to specific features of visual stimuli and their locomotor context, distinct from the signals carried by direct intracortical projections from V1. Thus, visual transthalamic pathways are functionally specific to their cortical target, different from feedforward cortical pathways, and combine information from multiple brain regions, linking sensory signals with behavioral context. |
